[The effect of benzylpenicillin and doxycycline on toxicity and antineoplastic action of cyclophosphamide and methotrexate in mice].

The effect of benzylpenicillin and doxycycline on toxicity and anticancer activity of cyclophosphamide and methotrexate in mice was studied. Benzylpenicillin applied both at once repeatedly enhances anticancer activity of cyclophosphamide against L 1210 leukemia within limited range of CP. Benzylpenicillin does not change anticancer activity of methotrexate, but doxycycline of both cyclophosphamide and methotrexate, against L 1210 leukemia in mice.