Porada M, Budzisz E, Graczyk J, Pakulska W
Zakład Chemii Nieorganicznej, Instytut Chemii, Akademia Medyczna, Lódź.
Acta Pol Pharm. 1993;50(2-3):173-8.
A series of N-derivatives of 2-phenyl-2,3-dihydro-1,3,2(lambda 5)- benzoxazaphosphoryl-4-one and 2-phenyl-10-methyl-3a-triethoxyphosphonio- 1H,2,3,9,10-tetrahydropyrrolo[3,4-b]([1,4]benzoxazepine-1,3,9-trio ne have been prepared. The pharmacological investigation of the above mentioned compounds shows antitumor action against leukaemia in the case of three N-derivatives.
已制备了一系列2-苯基-2,3-二氢-1,3,2(λ5)-苯并恶唑磷酰-4-酮和2-苯基-10-甲基-3a-三乙氧基磷酰基-1H,2,3,9,10-四氢吡咯并[3,4-b][1,4]苯并二氮杂卓-1,3,9-三酮的N-衍生物。上述化合物的药理研究表明,其中三种N-衍生物对白血病具有抗肿瘤作用。