2-取代的2,3-二氢-1,3,2-苯并氧杂磷杂环丁烷-4-酮及其2-氧化物衍生物的合成与抗癌活性
Synthesis and anticancer activity of 2-substituted 2,3-dihydro-1,3,2- benzoxazaphosphorin-4-one and its 2-oxide derivatives.
作者信息
Kostka K, Porada M, Graczyk J
机构信息
Institute of Chemistry, Faculty of Pharmacy, Medical University, Lodz, Poland.
出版信息
Arch Pharm (Weinheim). 1994 Apr;327(4):233-6. doi: 10.1002/ardp.19943270408.
PMID:8204022
Abstract
As a result of the reaction of salicylic amide with PCl3 and POCl3 2-chloro-2,3-dihydro-1,3,2-benzoxazaphosphorin-4-one (1) and its 2-oxide 2 are obtained. Compounds 1 and 2 form amides with amines in 2-position. Antineoplastic action of the derivatives containing the bis(2-chloroethyl)amide group in 2-position was found.
摘要
由于水杨酰胺与三氯化磷和三氯氧磷反应，得到了2-氯-2,3-二氢-1,3,2-苯并氧氮磷杂环丁烷-4-酮（1）及其2-氧化物2。化合物1和2在2-位与胺形成酰胺。发现了在2-位含有双（2-氯乙基）酰胺基团的衍生物的抗肿瘤作用。
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