Putney J W, Bird G S
Laboratory of Cellular and Molecular Pharmacology, National Institute of Environmental Health Sciences-NIH, Research Triangle Park, NC 27709.
Adv Exp Med Biol. 1994;350:115-9. doi: 10.1007/978-1-4615-2417-5_20.
From the above discussion, it is clear that the regulation of Ca2+ signalling in exocrine cells is a complex process involving activation of both intracellular Ca2+ release as well as the entry of Ca2+ across the plasma membrane. A poorly understood mechanism links these two phases of Ca2+ signalling thereby providing both rapid as well as sustained signals for the initiation and maintenance of appropriate exocrine responses. Further work is needed to better understand the mechanisms controlling this important and ubiquitous signalling system.
从上述讨论中可以清楚地看出，外分泌细胞中Ca2+信号的调节是一个复杂的过程，涉及细胞内Ca2+释放的激活以及Ca2+跨质膜的进入。一种尚未完全理解的机制将Ca2+信号的这两个阶段联系起来，从而为启动和维持适当的外分泌反应提供快速和持续的信号。需要进一步的研究来更好地理解控制这个重要且普遍存在的信号系统的机制。
