Sangueza O P, White C R
Department of Dermatology, Oregon Health Sciences University, Portland 97201.
Am J Dermatopathol. 1994 Apr;16(2):185-8. doi: 10.1097/00000372-199404000-00015.
Parachordomas are rare soft-tissue neoplasms that are histologically similar to chordomas. They typically develop adjacent to tendon, synovium, or osseous structures within extremities and present as slowly growing, locally destructive, lobulated neoplasms that are prone to recurrence if incompletely excised. We report a parachordoma occurring in the right middle finger of a 25-year-old man. The neoplasm had been present for 5 years, and the patient had sustained repeated injuries to the area. Histologically, the lesion was characterized by well-circumscribed lobules composed of small cellular aggregates, some in "alveolar" distribution, and single, large, vacuolated (physalipherous) cells embedded within a hyalin and chondroid matrix divided by fibrous trabeculae. Immunohistochemically, the parachordoma stained positively for the S-100 protein, vimentin, and cytokeratin.
副脊索瘤是一种罕见的软组织肿瘤，组织学上与脊索瘤相似。它们通常发生在四肢的肌腱、滑膜或骨结构附近，表现为生长缓慢、具有局部破坏性的分叶状肿瘤，如果切除不完全容易复发。我们报告一例发生在一名25岁男性右手中指的副脊索瘤。该肿瘤已存在5年，患者该部位曾反复受伤。组织学上，病变的特征是边界清楚的小叶，由小细胞聚集体组成，有些呈“肺泡状”分布，还有单个大的空泡状（泡状核）细胞嵌入由纤维小梁分隔的透明和软骨样基质中。免疫组化显示，副脊索瘤对S-100蛋白、波形蛋白和细胞角蛋白呈阳性染色。
