SON基因编码一种保守的DNA结合蛋白，定位于人类21号染色体。
The SON gene encodes a conserved DNA binding protein mapping to human chromosome 21.
作者信息
Khan I M, Fisher R A, Johnson K J, Bailey M E, Siciliano M J, Kessling A M, Farrer M, Carritt B, Kamalati T, Buluwela L
机构信息
Department of Biochemistry, Charing Cross and Westminster Medical School, University of London.
出版信息
Ann Hum Genet. 1994 Jan;58(1):25-34. doi: 10.1111/j.1469-1809.1994.tb00723.x.
We report the identification and characterization of a clone for the DNA binding protein SON, which we have isolated from a human keratinocyte cDNA library. Using this clone we have found that the SON gene is expressed in different cell types and that homologous sequences can be detected in vertebrate and insect genomic DNA. Using the polymerase chain reaction (PCR) to amplify SON sequences from a panel of somatic cell hybrids we have assigned the gene encoding human SON to chromosome 21. By use of hybrids containing regions of chromosome 21 the localization has been refined to 21q 22.1-q22.2.
我们报告了一种DNA结合蛋白SON克隆的鉴定和特性分析，该克隆是我们从人角质形成细胞cDNA文库中分离得到的。利用该克隆，我们发现SON基因在不同细胞类型中表达，并且在脊椎动物和昆虫的基因组DNA中可以检测到同源序列。通过聚合酶链反应（PCR）从一组体细胞杂种中扩增SON序列，我们将编码人SON的基因定位到了21号染色体上。利用包含21号染色体区域的杂种，定位已精确到21q22.1-q22.2。
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