Sakly R, Achour A, Zouaghi H
Ecole Supérieure des Sciences et Techniques de la Santé, Monastir, Tunisie.
Ann Urol (Paris). 1994;28(3):128-31.
Oxalate lithiasis was induced in control rats and rats previously given a vitamin A supplement for one week at the dose for 200 UI/d/kg body weight. Oxalate and calcium deposits in renal tissue measured 24 hours after the induction of lithiasis were found to be significantly lower in the vitamin A supplemented rats (p < 0.001 and p < 0.01) respectively). Renal function in these animals was also improved as compared with controls (p < 0.05). However, when vitamin A supplements were given for the same period and at the same dose, but after the induction of oxalate lithiasis, no difference regarding oxalate and calcium deposits was found between the two groups of animals. The same applied to renal function, which showed no improvement in the supplemented animals as compared with controls. These results suggest that vitamin A supplements have an inhibitory effect on lithogenesis but probably no litholytic action as such. The effect of vitamin A is probably related to its action on tubular cellular repair or an inhibitory effect on necrosis of these cells.
在对照大鼠和先前以200 UI/d/kg体重的剂量补充维生素A一周的大鼠中诱发草酸盐结石症。在诱发结石症24小时后测量发现，补充维生素A的大鼠肾组织中的草酸盐和钙沉积物分别显著低于对照组（p < 0.001和p < 0.01）。与对照组相比，这些动物的肾功能也得到了改善（p < 0.05）。然而，当在草酸盐结石症诱发后以相同的时期和相同的剂量给予维生素A补充剂时，两组动物之间在草酸盐和钙沉积物方面未发现差异。肾功能也是如此，与对照组相比，补充维生素A的动物肾功能没有改善。这些结果表明，维生素A补充剂对结石形成有抑制作用，但可能没有溶解结石的作用。维生素A的作用可能与其对肾小管细胞修复的作用或对这些细胞坏死的抑制作用有关。
