Taylor J L, Tom P, Guy J, Selvarajan R M, O'Brien W J
Department of Microbiology, Medical College of Wisconsin, Milwaukee 53226.
Antimicrob Agents Chemother. 1994 Apr;38(4):853-6. doi: 10.1128/AAC.38.4.853.
Alpha interferon (IFN-alpha) and acyclovir (ACV) are synergistic in their anti-herpes simplex virus activities. IFN-alpha treatment reduced the herpes simplex virus thymidine kinase (TK) activity present in cells 6 h postinfection, while steady-state levels of TK mRNA remained at or above the amount in infected, untreated cells. The inhibition of TK production by IFN-alpha treatment appeared to be transient and translational, not transcriptional.
α干扰素（IFN-α）和阿昔洛韦（ACV）在抗单纯疱疹病毒活性方面具有协同作用。IFN-α处理可降低感染后6小时细胞中存在的单纯疱疹病毒胸苷激酶（TK）活性，而TK mRNA的稳态水平保持在感染但未处理细胞中的水平或以上。IFN-α处理对TK产生的抑制作用似乎是短暂的且是翻译水平的，而非转录水平的。
