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一例伴有多发肝转移的晚期胃癌患者对使用5-氟尿嘧啶、吡柔比星和丝裂霉素(FTM)的新联合化疗表现出显著反应

[A case of advanced gastric cancer with multiple liver metastases showing marked response to new combination chemotherapy using 5-FU, THP and MMC (FTM)].

作者信息

Sakai Y, Kusano F, Yamamoto C, Maekawa N, Sasaki N, Tajiri K, Tazawa J

机构信息

Dept. of Internal Medicine, Tsuchiura Kyodo General Hospital.

出版信息

Gan To Kagaku Ryoho. 1994 Jul;21(8):1271-4.

PMID:8031171
Abstract

A 67-year-old man with advanced gastric cancer with multiple liver metastases was treated by a new combination chemotherapy using 5-FU, THP and MMC (FTM). After the first course of FTM, both abnormal liver function and the elevated level of serum CA 19-9 were restored. After the second course of FTM, the primary lesion became a small ulcer around cardia. A partial response was recognized both in the primary lesion and in the liver metastases. No serious side effect was observed except for leukocytopenia, which was controlled by G-CSFS. This new combination chemotherapy (FTM) was suggested to be useful even for far advanced gastric cancer.

摘要

一名67岁患有晚期胃癌并伴有多处肝转移的男性患者接受了使用5-氟尿嘧啶、吡柔比星和丝裂霉素(FTM)的新型联合化疗。在FTM的第一个疗程后,肝功能异常和血清CA 19-9水平升高均恢复正常。在FTM的第二个疗程后,原发灶变为贲门周围的一个小溃疡。原发灶和肝转移灶均出现部分缓解。除白细胞减少症外未观察到严重副作用,白细胞减少症通过粒细胞集落刺激因子得到控制。这种新型联合化疗(FTM)被认为即使对晚期胃癌也有效。

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