Li Q, Bowmer C J, Yates M S
Department of Pharmacology, University of Leeds, U.K.
Biochem Pharmacol. 1994 Jun 15;47(12):2298-301. doi: 10.1016/0006-2952(94)90269-0.
The effect of arginine on the nephrotoxicity produced by cisplatin (6.0 mg/kg i.v.) was investigated in the rat. Intravenous administration of L-arginine at doses of 0.26-2.63 g/kg at the time of cisplatin injection produced significant protection of renal function as evidenced by reductions in plasma urea and creatinine concentrations, decreased polyuria and increases in the plasma clearance of [3H]inulin and [14C]-p aminohippurate. Administration of D-arginine (2.63 g/kg i.v.) also significantly ameliorated the renal dysfunction induced by cisplatin although this protective effect was not as great as produced by the same dose of L-arginine. D-arginine, by contrast to its L-isomer, is reported to have little or no effect on renal haemodynamics. Consequently, the results of this study indicate that the protective effect of L-arginine in cisplatin nephrotoxicity involves both haemodynamic and nonhaemodynamic components.
在大鼠中研究了精氨酸对顺铂（6.0毫克/千克静脉注射）所致肾毒性的影响。在注射顺铂时静脉注射剂量为0.26 - 2.63克/千克的L - 精氨酸，可显著保护肾功能，表现为血浆尿素和肌酐浓度降低、多尿减少以及[3H]菊粉和[14C] - 对氨基马尿酸的血浆清除率增加。静脉注射D - 精氨酸（2.63克/千克）也显著改善了顺铂诱导的肾功能障碍，尽管这种保护作用不如相同剂量的L - 精氨酸显著。与L - 异构体相比，据报道D - 精氨酸对肾血流动力学几乎没有影响。因此，本研究结果表明L - 精氨酸对顺铂肾毒性的保护作用涉及血流动力学和非血流动力学成分。
