Nematbakhsh Mehdi, Pezeshki Zahra, Eshraghi Jazi Fatemeh, Mazaheri Bahar, Moeini Maryam, Safari Tahereh, Azarkish Fariba, Moslemi Fatemeh, Maleki Maryam, Rezaei Alireza, Saberi Shadan, Dehghani Aghdas, Malek Maryam, Mansouri Azam, Ghasemi Marzieh, Zeinali Farzaneh, Zamani Zohreh, Navidi Mitra, Jilanchi Sima, Shirdavani Soheyla, Ashrafi Farzaneh
Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran. *Email:
Asian Pac J Cancer Prev. 2017 Feb 1;18(2):295-314. doi: 10.22034/APJCP.2017.18.2.295.
Cisplatin (CDDP) has been widely used as a chemotherapeutic agent for solid tumors. The most common side effect of CDDP is nephrotoxicity, and many efforts have been made in the laboratory and the clinic to employ candidate adjuvants to CDDP to minimize this adverse influence. Many synthetic and herbal antioxidants as well as trace elements have been investigated for this purpose in recent years and a variety of positive and negative results have been yielded. However, no definitive supplement has so far been proposed to prevent CDDP-induced nephrotoxicity; however, this condition is gender related and the sex hormone estrogen may protect the kidney against CDDP damage. In this review, the results of research related to the effect of different synthetic and herbal antioxidants supplements are presented and discussed with suggestions included for future work.
顺铂（CDDP）已被广泛用作实体瘤的化疗药物。CDDP最常见的副作用是肾毒性，实验室和临床已经做出了许多努力，采用CDDP的候选佐剂来尽量减少这种不利影响。近年来，许多合成和草药抗氧化剂以及微量元素都为此进行了研究，并产生了各种正面和负面的结果。然而，迄今为止，尚未提出明确的补充剂来预防CDDP诱导的肾毒性；然而，这种情况与性别有关，性激素雌激素可能保护肾脏免受CDDP损伤。在这篇综述中，介绍并讨论了与不同合成和草药抗氧化剂补充剂效果相关的研究结果，并为未来的工作提出了建议。
