Urquhart J
APREX Corporation, Fremont, CA 94538.
Br J Clin Pract Suppl. 1994 May;73:2-12.
New and more reliable techniques to assess patients' compliance with their prescribed drug regimen have shown that the problem of poor and partial compliance is much greater than was originally anticipated. This paper reviews the new methods available to assess patient compliance and how these methods have revealed new patterns of partial compliance. The problems associated with unrecognised partial compliance in the evaluation of drugs and the assessment of certain clinical problems are also discussed, together with the potential risks to the patient. Finally, this article addresses the issue of minimising the impact of partial compliance by using 'forgiving' drugs, such as longer-acting agents, rather than 'demanding' drugs eg, short-acting agents.
用于评估患者对规定药物治疗方案依从性的更新且更可靠的技术表明，依从性差和部分依从的问题比最初预期的要严重得多。本文回顾了可用于评估患者依从性的新方法，以及这些方法如何揭示了部分依从的新模式。还讨论了在药物评估和某些临床问题评估中与未被认识到的部分依从性相关的问题，以及对患者的潜在风险。最后，本文探讨了通过使用“宽容型”药物（如长效制剂）而非“严格型”药物（如短效制剂）来尽量减少部分依从性影响的问题。
