Hendrickson H P, Kaufman A D, Lunte C E
Department of Chemistry, University of Kansas, Lawrence 66045-0049.
J Pharm Biomed Anal. 1994 Mar;12(3):325-34. doi: 10.1016/0731-7085(94)90007-8.
The electrochemical properties of four structurally related flavonoids, quercetin, quercetin-3-O-rhamnose (quercitrin), quercetin-3-O-rutinose (rutin) and luteolin were investigated. These flavonoids were shown to undergo homogenous chemical reactions following oxidation at a glassy carbon electrode. These reactions were studied using cyclic voltammetry and rotating ring-disk voltammetry. Both first-order and zero-order processes were observed. The rate of the zero-order process was strongly dependent on the substituent at the C-3 position of the flavonoid. The rate of the first-order process was independent of substitution. Two products were observed using liquid chromatography. These products did not correspond to previously reported products of enzymatic oxidation. The products were not stable under conditions for isolation.
研究了四种结构相关的黄酮类化合物槲皮素、槲皮素-3-O-鼠李糖（金丝桃苷）、槲皮素-3-O-芸香糖（芦丁）和木犀草素的电化学性质。这些黄酮类化合物在玻碳电极上氧化后会发生均相化学反应。使用循环伏安法和旋转环盘伏安法对这些反应进行了研究。观察到了一级和零级过程。零级过程的速率强烈依赖于黄酮类化合物C-3位的取代基。一级过程的速率与取代无关。使用液相色谱法观察到了两种产物。这些产物与先前报道的酶促氧化产物不对应。这些产物在分离条件下不稳定。
