Plapp B V
Department of Biochemistry, University of Iowa, Iowa City 52242.
EXS. 1994;71:311-22. doi: 10.1007/978-3-0348-7330-7_31.
The rate of alcohol metabolism is determined by the kinetic characteristics and concentrations of the alcohol and aldehyde dehydrogenases and by the rate of restoration of the redox state of the cell. Several potent competitive and uncompetitive inhibitors of the alcohol dehydrogenases can decrease the rate of alcohol metabolism; they may be useful for preventing the potentially deleterious effects of ethanol metabolism. Alcohol dehydrogenases have very broad specificity and can readily reduce a variety of carbonyl compounds by exchange reactions while ethanol is metabolized. Agents that increase the rate of metabolism need to be developed.
酒精代谢速率由乙醇脱氢酶和乙醛脱氢酶的动力学特征及浓度，以及细胞氧化还原状态的恢复速率决定。几种有效的乙醇脱氢酶竞争性和非竞争性抑制剂可降低酒精代谢速率；它们可能有助于预防乙醇代谢的潜在有害影响。乙醇脱氢酶具有非常广泛的特异性，在乙醇代谢时可通过交换反应轻易还原多种羰基化合物。需要研发提高代谢速率的药物。
