Zorzano A, Herrera E
Departamento de Bioquímica y Fisiología, Facultad de Biología, Universidad de Barcelona, Spain.
Life Sci. 1990;46(3):223-30. doi: 10.1016/0024-3205(90)90108-4.
The in vivo ethanol elimination in human subjects, monkeys and rats was investigated after an oral ethanol dosage. After 0.4 g. ethanol/kg of body weight, ethanol elimination was much slower in human subjects than in monkeys. In order to detect a rise in monkey plasma ethanol concentrations as early as observed in human subjects, ethanol had to be administered at a dose of 3 g/kg body weight. Ethanol metabolism in rats was also much faster than in human subjects. However, human liver showed higher alcohol dehydrogenase activity and higher low Km aldehyde dehydrogenase activity than rat liver. Thus, our data suggest a lack of relationship between hepatic ethanol-metabolizing activities and the in vivo ethanol elimination rate.
在口服乙醇剂量后，对人类受试者、猴子和大鼠的体内乙醇消除情况进行了研究。给予0.4克乙醇/千克体重后，人类受试者体内乙醇的消除比猴子慢得多。为了像在人类受试者中观察到的那样尽早检测到猴子血浆乙醇浓度的升高，必须以3克/千克体重的剂量给予乙醇。大鼠体内的乙醇代谢也比人类受试者快得多。然而，人类肝脏显示出比大鼠肝脏更高的乙醇脱氢酶活性和更高的低Km乙醛脱氢酶活性。因此，我们的数据表明肝脏乙醇代谢活性与体内乙醇消除率之间缺乏关联。
