Dunderdale H J, West S C
Department of Genetic Recombination, Imperial Cancer Research Fund, Clare Hall Laboratories, South Mimms, Hertfordshire, UK.
Curr Opin Genet Dev. 1994 Apr;4(2):221-8. doi: 10.1016/s0959-437x(05)80048-6.
The recombination of DNA takes place by a multistep process involving numerous gene products. In the past year, studies using bacterial proteins have led to a number of significant advances in our understanding of the enzymes of recombination and of the reactions that they catalyze. Moreover, the identification of eukaryotic proteins that are structurally analogous to the principal bacterial recombination enzyme, RecA protein, suggests that the basic mechanisms of homologous pairing and strand exchange have been conserved through evolution from bacteria to man.
DNA重组通过一个涉及众多基因产物的多步骤过程发生。在过去的一年里，利用细菌蛋白进行的研究在我们对重组酶及其催化反应的理解方面取得了许多重大进展。此外，对与主要细菌重组酶RecA蛋白结构相似的真核蛋白的鉴定表明，从细菌到人类的进化过程中，同源配对和链交换的基本机制一直得以保留。
