Van Reeth O, Zhang Y, Zee P C, Turek F W
Department of Neurobiology/Physiology, Northwestern University, Evanston, IL 60208.
Brain Res. 1994 Apr 18;643(1-2):338-42. doi: 10.1016/0006-8993(94)90044-2.
In the present study, 18-25-month-old hamsters free-running in constant dim light were injected, both before and after receiving fetal grafts containing either cerebellar tissue or the suprachiasmatic nuclei (SCN), with a dose of triazolam given at a time known to reliably phase shift the rhythm of locomotor activity in young hamsters. SCN-grafted animals, but not control animals implanted with fetal cerebellar tissue, showed a significantly greater response to the phase shifting effects of triazolam, demonstrating that at least some age-related changes in the circadian system can be reversed by neuronal transplantation. These results raise the possibility that neuropharmacological interventions that can simulate the effects of fetal SCN grafts might be useful in the treatment of age-related disorders in circadian function.
在本研究中，在持续昏暗光线下自由活动的18至25月龄仓鼠，在接受含有小脑组织或视交叉上核（SCN）的胎儿移植物之前和之后，均注射了一剂三唑仑，给药时间是已知能可靠地使幼年仓鼠运动活动节律发生相位偏移的时间。移植了SCN的动物，而非植入胎儿小脑组织的对照动物，对三唑仑的相位偏移效应表现出显著更大的反应，这表明昼夜节律系统中至少一些与年龄相关的变化可通过神经元移植得到逆转。这些结果提出了一种可能性，即能够模拟胎儿SCN移植物效应的神经药理学干预措施可能对治疗与年龄相关的昼夜节律功能障碍有用。
