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Cloning a novel human brain inward rectifier potassium channel and its functional expression in Xenopus oocytes.

作者信息

Tang W, Yang X C

机构信息

Department of CNS Research, Lederle Laboratories, American Cyanamid Co., Pearl River, NY 10965.

出版信息

FEBS Lett. 1994 Jul 18;348(3):239-43. doi: 10.1016/0014-5793(94)00612-1.

DOI:10.1016/0014-5793(94)00612-1
PMID:8034048
Abstract

We have cloned a novel inward rectifier K+ channel (hIRK2) from a human frontal cortex cDNA library. The amino acid sequence of hIRK2 shares 60% and 40% identity with the mouse IRK1 and the rat ROMK1 channels, respectively. Xenopus oocytes injected with hIRK2 cRNA showed an inwardly rectifying K+ current that had a prominent 'N-shape' I-V curve and was blocked by extracellular Ba2+. The hIRK2 channel has two unique features: (a) an 18 amino acid insertion between the first transmembrane region and the pore, and (b) restricted mRNA distribution found only in human brain and heart.

摘要

相似文献

1
Cloning a novel human brain inward rectifier potassium channel and its functional expression in Xenopus oocytes.
FEBS Lett. 1994 Jul 18;348(3):239-43. doi: 10.1016/0014-5793(94)00612-1.
2
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引用本文的文献

1
Regulation of a family of inwardly rectifying potassium channels (Kir2) by the m1 muscarinic receptor and the small GTPase Rho.M1毒蕈碱受体和小GTP酶Rho对内向整流钾通道家族（Kir2）的调节作用
Pflugers Arch. 2006 May;452(2):164-74. doi: 10.1007/s00424-005-0014-9. Epub 2005 Nov 19.
2
Kir2.4 and Kir2.1 K(+) channel subunits co-assemble: a potential new contributor to inward rectifier current heterogeneity.Kir2.4与Kir2.1钾离子通道亚基共同组装：内向整流电流异质性的潜在新因素。
J Physiol. 2002 Oct 15;544(2):337-49. doi: 10.1113/jphysiol.2002.026047.
3
Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome.
Kir2.x钾通道的异源二聚化导致安德森综合征的表型。
Proc Natl Acad Sci U S A. 2002 May 28;99(11):7774-9. doi: 10.1073/pnas.102609499.
4
Comparison of cloned Kir2 channels with native inward rectifier K+ channels from guinea-pig cardiomyocytes.克隆的Kir2通道与豚鼠心肌细胞天然内向整流钾通道的比较。
J Physiol. 2001 Apr 1;532(Pt 1):115-26. doi: 10.1111/j.1469-7793.2001.0115g.x.
5
Effects of intra- and extracellular acidifications on single channel Kir2.3 currents.细胞内和细胞外酸化对单通道Kir2.3电流的影响。
J Physiol. 1999 May 1;516 ( Pt 3)(Pt 3):699-710. doi: 10.1111/j.1469-7793.1999.0699u.x.
6
Effects of divalent cations on the E-4031-sensitive repolarization current, I(Kr), in rabbit ventricular myocytes.二价阳离子对兔心室肌细胞中E-4031敏感的复极电流I(Kr)的影响。
Biophys J. 1998 Mar;74(3):1278-85. doi: 10.1016/S0006-3495(98)77841-5.
7
IRK(1-3) and GIRK(1-4) inwardly rectifying K+ channel mRNAs are differentially expressed in the adult rat brain.内向整流钾通道IRK(1 - 3)和GIRK(1 - 4)的信使核糖核酸在成年大鼠大脑中差异表达。
J Neurosci. 1996 Jun 1;16(11):3559-70. doi: 10.1523/JNEUROSCI.16-11-03559.1996.
8
Functional expression of a vertebrate inwardly rectifying K+ channel in yeast.脊椎动物内向整流钾离子通道在酵母中的功能表达。
Mol Biol Cell. 1995 Sep;6(9):1231-40. doi: 10.1091/mbc.6.9.1231.
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Physiological and molecular characterization of an IRK-type inward rectifier K+ channel in a tumour mast cell line.肿瘤肥大细胞系中一种IRK型内向整流钾离子通道的生理和分子特征
Pflugers Arch. 1995 Apr;429(6):809-19. doi: 10.1007/BF00374805.