Marana R, Muzii L, Catalano G F, Caruana P, Mancuso S
Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy.
Gynecol Obstet Invest. 1996;41(3):199-202. doi: 10.1159/000292268.
The present study was undertaken to compare adhesion formation and reproductive outcome after reproductive surgery with or without the application of fibrin sealant. At laparotomy, the ovaries and uterine horns of 20 rabbits were longitudinally incised on the antimesenteric side using a monopolar microneedle. At random, one ovary and the ipsilateral uterine horn were covered with fibrin sealant, while those on the contralateral side were left uncovered without application of sutures. The rabbits were then mated, and 2 weeks later a second-look laparotomy was performed by a blinded observer. No statistically significant differences were found in postoperative adhesions, number of corpora lutea in each ovary, number of embryos in the ipsilateral uterine horn, and nidation index for each side. Fibrin sealant for conservative surgery does not appear to significantly affect either postoperative adhesion formation or reproductive outcome.
本研究旨在比较在生殖手术中应用或不应用纤维蛋白封闭剂后的粘连形成情况及生殖结局。在剖腹手术中，使用单极微针在20只兔子的卵巢和子宫角的肠系膜对侧进行纵向切开。随机将一侧卵巢和同侧子宫角用纤维蛋白封闭剂覆盖，而对侧则不覆盖且不进行缝合。然后让兔子交配，2周后由一位不知情的观察者进行二次剖腹探查。在术后粘连、每个卵巢中的黄体数量、同侧子宫角中的胚胎数量以及每侧的着床指数方面，未发现统计学上的显著差异。用于保守手术的纤维蛋白封闭剂似乎对术后粘连形成或生殖结局均无显著影响。
