Shushan A, Simon A, Reubinoff B E, Lewin A, Schenker J G, Laufer N
Department of Obstetrics and Gynecology, Hadassah Ein-Karem Medical Center, Jerusalem, Israel.
Fertil Steril. 1994 Aug;62(2):412-4. doi: 10.1016/s0015-0282(16)56900-3.
Nine women enrolled in the donor egg program received in a preparatory cycle 6 mg of E2 by vaginal tablets two times per day for the first 14 days, followed by a combined preparation of 6 mg of E2 and 50 mg of P as vaginal tablets, two times per day for another 14 days. Adequate serum levels of E2 and P and favorable sonographic endometrial thickness were achieved throughout the cycle in all patients. Eight endometrial biopsies taken on days 25 to 26 were independently assessed as being representative of day 25 +/- 2. One endometrial biopsy was out of phase. It is concluded that vaginal tablets of E2, followed by a combined preparation of vaginal tablets of E2 and P, is an effective method for establishing an appropriately developed endometrium in a donor oocyte program. Endometrial preparation in donor oocyte programs can be simplified by the use of these tablets.
9名参加供卵计划的女性在准备周期中，前14天每天两次经阴道给予6毫克雌二醇片剂，随后14天每天两次经阴道给予含6毫克雌二醇和50毫克孕酮的复方制剂。所有患者在整个周期中均达到了足够的雌二醇和孕酮血清水平，且子宫内膜超声厚度良好。在第25至26天采集的8份子宫内膜活检样本经独立评估，被认为代表第25±2天的情况。1份子宫内膜活检样本不同步。结论是，先给予雌二醇阴道片剂，随后给予雌二醇和孕酮复方阴道片剂，是在供卵计划中建立发育适当的子宫内膜的有效方法。使用这些片剂可简化供卵计划中的子宫内膜准备过程。
