Simon J A, Rodi I A, Stumpf P G, Sauer M V, Cohen S W, Ford L C, Bustillo M, Buster J E
Fertil Steril. 1986 Oct;46(4):619-25.
17 beta-estradiol (E2)-and/or crystalline progesterone (P)-impregnated polysiloxane vaginal rings and cylinders were tested as a system for endometrial priming in functionally agonadal women awaiting donor embryo transfer. Endometrial tissue was obtained by a transcervical biopsy procedure on simulated cycle day 26. The adequacy of the replacement regimen was judged by endometrial histologic dating, scanning electron micrographs, receptor content, and circulating E2 and P serum concentrations. Endometrial dating was consistent with cycle day 26. Electron micrographs showed normal surface characteristics. E2 and P receptor concentrations were within the normal range. Serum E2 levels were midfollicular, 105 +/- 12.8 pg/ml (mean +/- SEM), and midcycle, 254 +/- 28.6 pg/ml. P levels during the simulated follicular phase were undetectable (less than 0.2 ng/ml) but rose to a mean peak level of 17.3 +/- 1.8 ng/ml. The steroid-impregnated polysiloxane vaginal ring and cylinder system provided continuous and sustained hormone release, morphologically and endocrinologically normal endometrium, serum levels of E2 and P within the normal range for the entire menstrual cycle, and a convenient and physiologic therapeutic alternative to oral, vaginal, or intramuscular steroid replacement.
对17β-雌二醇（E2）和/或结晶孕酮（P）浸渍的聚硅氧烷阴道环和柱状体进行了测试，作为等待供体胚胎移植的功能性性腺功能减退女性子宫内膜预处理的一种系统。在模拟周期的第26天，通过经宫颈活检程序获取子宫内膜组织。通过子宫内膜组织学分期、扫描电子显微镜照片、受体含量以及循环E2和P血清浓度来判断替代方案的充分性。子宫内膜分期与周期第26天一致。电子显微镜照片显示表面特征正常。E2和P受体浓度在正常范围内。血清E2水平在卵泡中期为105±12.8 pg/ml（平均值±标准误），在周期中期为254±28.6 pg/ml。在模拟卵泡期P水平检测不到（低于0.2 ng/ml），但升至平均峰值水平17.3±1.8 ng/ml。类固醇浸渍的聚硅氧烷阴道环和柱状体系统提供持续且稳定的激素释放，形态学和内分泌学上正常的子宫内膜，整个月经周期内E2和P的血清水平在正常范围内，并且是口服、阴道或肌肉注射类固醇替代的一种方便且生理性的治疗选择。
