Tziafas D
Department of Dental Pathology and Therapeutics, School of Dentistry, Aristotle University of Thessaloniki, Greece.
Int Endod J. 1994 Mar;27(2):61-74. doi: 10.1111/j.1365-2591.1994.tb00233.x.
Dentinogenesis can be initiated secondarily as an intrinsic ability of the dental pulp to repair, or after interaction of pulp cells with specific exogenous inductive factors. In the present article the basic developmental aspects, highlighting the mechanism by which dentinogenesis is initiated during tooth development, are discussed. Furthermore, clinical and experimental observations concerning the events taking place during secondary initiation of dentine formation, as part of exposed or non-exposed pulp tissue repair, or as a result of dentine matrix or other chemical-pulp cell interactions, are reviewed. Discussion includes hypotheses relating to the crucial biological steps leading to expression of odontoblastic-like cell phenotype and secondary initiation of dentine histogenesis.
牙本质形成可以作为牙髓修复的一种内在能力而继发启动，或者在牙髓细胞与特定外源性诱导因子相互作用后启动。在本文中，将讨论牙本质形成在牙齿发育过程中起始的基本发育方面，重点阐述其机制。此外，还将综述有关牙本质形成继发启动过程中发生的事件的临床和实验观察结果，这些事件是暴露或未暴露牙髓组织修复的一部分，或者是牙本质基质或其他化学物质与牙髓细胞相互作用的结果。讨论内容包括与导致成牙本质样细胞表型表达和牙本质组织发生继发启动的关键生物学步骤相关的假说。
