Soyez D, Van Herp F, Rossier J, Le Caer J P, Tensen C P, Lafont R
Laboratoire de Biochimie et Physiologie du Développement, URA CNRS 686, Ecole Normale Supérieure, Paris, France.
J Biol Chem. 1994 Jul 15;269(28):18295-8.
Several large peptidic neurohormones have been isolated in crustaceans. In lobster and other related species, each of these neurohormones, and particularly the crustacean hyperglycemic hormone, occurs as two isoforms having the same peptidic sequence and molecular mass. We report here that these isoforms differ by the configuration of a single amino acid residue. The third residue (Phe3) of the lobster hyperglycemic hormones is in either the L- or D-configuration. In addition, we have shown that the biological activity of the two isoforms differs when considering the kinetics of their hyperglycemic effect.
在甲壳类动物中已分离出几种大型肽类神经激素。在龙虾和其他相关物种中，这些神经激素中的每一种，尤其是甲壳类动物高血糖激素，都以具有相同肽序列和分子量的两种异构体形式存在。我们在此报告，这些异构体的区别在于单个氨基酸残基的构型。龙虾高血糖激素的第三个残基（Phe3）为L型或D型构型。此外，我们还表明，考虑到它们高血糖作用的动力学，这两种异构体的生物活性有所不同。
