Goerdt S, Bonsmann G, Sunderkötter C, Grabbe S, Luger T, Kolde G
Department of Dermatology, University of Münster, Germany.
J Am Acad Dermatol. 1994 Aug;31(2 Pt 2):322-6. doi: 10.1016/s0190-9622(94)70164-4.
A symmetric eruption of hundreds of coalescent small red macules and a few slightly elevated papules sparing the flexures was observed in a 73-year-old man. Light microscopic examination showed loose aggregates of small and large histiocytic cells. Electron microscopy showed an absence of Langerhans cell granules and lipid droplets. Features shared with generalized eruptive histiocytoma were the symmetry of the eruption sparing the flexures, the blue-red coloration, and the absence of lipid-containing foam cells and multinucleated giant cells. However, the primary occurrence of macules rather than papules or nodules, the tendency of the macules to coalesce, and the dimorphic histiocytoid infiltrate are not found in generalized eruptive histiocytoma. Nevertheless, immunohistochemistry confirmed that this unique condition is a form of MS-1+ cutaneous non-Langerhans cell histiocytosis.
在一名73岁男性身上观察到数百个融合性小红斑及少数轻度隆起丘疹的对称性皮疹，屈侧未受累。光镜检查显示大小组织细胞的松散聚集。电镜检查显示无朗格汉斯细胞颗粒和脂滴。与泛发性发疹性组织细胞瘤共有的特征包括皮疹对称、屈侧未受累、蓝红色泽、无含脂质的泡沫细胞和多核巨细胞。然而，泛发性发疹性组织细胞瘤中未发现以斑疹而非丘疹或结节为主、斑疹融合倾向及双形性组织细胞样浸润。尽管如此，免疫组化证实这种独特情况是MS-1+皮肤非朗格汉斯细胞组织细胞增多症的一种形式。
