Winkelmann R K, Kossard S, Fraga S
Arch Dermatol. 1980 May;116(5):565-70.
A 9-year-old girl had a widespread papular eruption that was histologically characterized by benign histiocytes that were acid phosphatase-positive, but that lacked Langerhans' granules ultrastructurally. New lesions had continued to develop since the patient was 3 months old, and individual lesions had resolved over a period of two to three months. The histopathologic, histochemical, and ultrastructural findings in this patient were similar to those previously described for eruptive histiocytomas in adults. Papular histiocytomas in childhood may be found in histiocytosis X, reticulohistiocytoma, xanthogranuloma, xanthoma disseminatum, or eruptive histiocytoma. These diseases may be differentiated on the basis of differing histiocytic populations and the clinical courses of the lesions in each disorder.
一名9岁女孩出现广泛的丘疹性皮疹，组织学特征为良性组织细胞，酸性磷酸酶呈阳性，但超微结构缺乏朗格汉斯颗粒。自患者3个月大以来，新的皮疹持续出现，单个皮疹在两到三个月内消退。该患者的组织病理学、组织化学和超微结构表现与先前描述的成人爆发性组织细胞瘤相似。儿童期丘疹性组织细胞瘤可见于组织细胞增多症X、网状组织细胞瘤、黄色肉芽肿、播散性黄瘤或爆发性组织细胞瘤。这些疾病可根据不同的组织细胞群体以及每种疾病中病变的临床过程进行鉴别。
