Anderson T J, Meredith I T, Ganz P, Selwyn A P, Yeung A C
Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.
J Am Coll Cardiol. 1994 Aug;24(2):555-66. doi: 10.1016/0735-1097(94)90316-6.
Many similarities exist between the exogenous nitrates and endothelium-derived relaxing factor, which is nitric oxide or a thiol derivative. Both act by way of guanylate cyclase, which increases intracellular concentrations of cyclic guanosine monophosphate, resulting in smooth muscle cell relaxation and antiplatelet effects. Thiols may be important in the biotransformation of exogenous nitrates and other intracellular processes involving nitric oxide. As such, important interactions might be expected between nitrates and endothelium-dependent processes that involve nitric oxide. This review explores the mechanisms of action, biologic effects and potential interactions between nitrates and endothelium-derived relaxing factor.
外源性硝酸盐与内皮源性舒张因子（即一氧化氮或硫醇衍生物）之间存在许多相似之处。两者均通过鸟苷酸环化酶起作用，该酶可增加细胞内环磷酸鸟苷的浓度，从而导致平滑肌细胞舒张和抗血小板作用。硫醇在外源性硝酸盐的生物转化以及涉及一氧化氮的其他细胞内过程中可能很重要。因此，预计硝酸盐与涉及一氧化氮的内皮依赖性过程之间可能会有重要的相互作用。本综述探讨了硝酸盐与内皮源性舒张因子之间的作用机制、生物学效应及潜在的相互作用。
