Lloyd D A, Payton K B, Guenther L, Frydman W
Division of Gastroenterology, St. Joseph's Health Centre, London, Ontario, Canada.
J Clin Gastroenterol. 1994 Apr;18(3):213-7.
In 1985, a 19-year-old woman had clinical features suggesting anorectal Crohn's disease. Two years later, swelling of the vulva associated with perianal swelling developed. The clinical manifestations responded to oral prednisone until 1989, when she returned with a swelling of the upper lip, a polypoid lesion of the oral buccal mucosa, and swelling of the anus and vulva. The lip biopsy demonstrated granulomas. The illness failed to respond to systemic immunosuppressive therapy, wider consultation was made, and the diagnosis of the Melkersson-Rosenthal syndrome was made. Such an appearance of this rare condition is unusual. We describe her case and discuss the literature, raising the possibility that the Melkersson-Rosenthal syndrome and Crohn's disease are the same condition with different initial clinical appearances.
1985年，一名19岁女性出现提示肛门直肠克罗恩病的临床特征。两年后，出现外阴肿胀并伴有肛周肿胀。直到1989年，口服泼尼松对临床表现有效果，当时她再次就诊时出现上唇肿胀、口腔颊黏膜息肉样病变以及肛门和外阴肿胀。唇部活检显示有肉芽肿。该疾病对全身免疫抑制治疗无反应，于是进行了更广泛的会诊，并诊断为梅尔克森－罗森塔尔综合征。这种罕见疾病的如此表现并不常见。我们描述了她的病例并讨论相关文献，提出梅尔克森－罗森塔尔综合征和克罗恩病可能是具有不同初始临床表现的同一疾病的可能性。
