Tonkovic-Capin V, Galbraith S S, Rogers R S, Binion D G, Yancey K B
Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI, USA.
J Eur Acad Dermatol Venereol. 2006 Apr;20(4):449-52. doi: 10.1111/j.1468-3083.2006.01458.x.
A woman with a 5-year history of unilateral orofacial granulomatosis required repeated evaluations (including sequential colonoscopies) to establish the diagnosis of cutaneous Crohn's disease, a condition that proved responsive to low doses of oral methotrexate administered weekly. To our knowledge this is the first report describing the use of methotrexate for treatment of orofacial granulomatosis caused by underlying Crohn's disease.
一名患有单侧口面部肉芽肿病5年的女性需要反复评估（包括连续结肠镜检查）以确诊皮肤克罗恩病，事实证明低剂量口服甲氨蝶呤每周给药对此病有效。据我们所知，这是首篇描述使用甲氨蝶呤治疗潜在克罗恩病所致口面部肉芽肿病的报告。
