Younes S, Baziard-Mouysset G, Stigliani J L, Payard M, Bonnafous R, Tisne-Versailles J
Faculté de Pharmacie, Toulouse.
J Pharm Belg. 1994 Mar-Apr;49(2):119-25.
Two sets of phosphonic diethylester including a substituted benzylpiperazine moiety are synthesized. In spite of the spasmolytic or the calcium antagonistic potentialities of benzylpiperazine and phosphonic moieties, none of the six compounds, tested in vitro, exhibit any calcium antagonistic profile.