[（+）-前胡素A的结构修饰研究]
[Studies on structure modification of (+)-praeruptorin A].
作者信息
Wu Xian-li, Kong Ling-yi, Min Zhi-da
机构信息
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210038, China.
出版信息
Yao Xue Xue Bao. 2002 Jul;37(7):527-34.
AIM
In order to look for new active compounds, the structure of (+)-praeruptorin A is modified.
METHODS
(+)-Praeruptorin A was isolated from the root of Peucedanum praeruptorum, basic hydrolysis of (+)-praeruptorin A and acyled reactions of hydrolysis product of (+)-praeruptorin A were carried out.
RESULTS
Eighteen compounds were semi-synthesized from (+)-praeruptorin A.
CONCLUSION
Fourteen compounds (5-18) among them are new compounds. Preliminary bioactivity assay indicated that the new compounds show calcium antagonist activity, but they are not as strong as (+)-praeruptorin A.
目的
为寻找新的活性化合物，对（+）-前胡素A的结构进行修饰。
方法
从白花前胡根中分离得到（+）-前胡素A，对其进行碱性水解以及水解产物的酰化反应。
结果
由（+）-前胡素A半合成了18个化合物。
结论
其中14个化合物（5 - 18）为新化合物。初步生物活性测定表明，这些新化合物具有钙拮抗剂活性，但活性不如（+）-前胡素A强。
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