Fafalak R G, Peterson M G, Kagen L J
Department of Medicine, Hospital for Special Surgery, New York, NY 10021.
J Rheumatol. 1994 Apr;21(4):643-8.
To study the influence of clinical variables on improvement in muscle strength in patients with polymyositis and dermatomyositis.
We biomechanically examined muscle strength over the course of 2.54 years of 65 patients.
Disease duration before therapy was predictive of outcome. Those treated within 6 months or one year of disease onset had better outcomes than those with later treatment. In addition, among those who gained strength, degree of elevation of creatine kinase was correlated with greater gains.
Early treatment after disease onset increases the chance of a favorable response.
研究临床变量对多发性肌炎和皮肌炎患者肌肉力量改善的影响。
我们对65例患者在2.54年的病程中进行了肌肉力量的生物力学检查。
治疗前的病程可预测预后。在疾病发作后6个月或1年内接受治疗的患者比治疗较晚的患者预后更好。此外，在那些肌肉力量增加的患者中，肌酸激酶升高的程度与更大的力量增加相关。
疾病发作后早期治疗可增加获得良好反应的机会。
