嗜酸性粒细胞增多性肌痛综合征骨骼肌的磷-31磁共振波谱分析：一项初步研究。
P-31 magnetic resonance spectroscopy of skeletal muscle in the eosinophilia-myalgia syndrome: a preliminary study.
作者信息
Clauw D J, Hewes B, Nelson M, Katz P, Rajan S
机构信息
Department of Radiology, Georgetown University Medical Center, Washington, DC 20007.
出版信息
J Rheumatol. 1994 Apr;21(4):654-7.
OBJECTIVE
To determine the pathogenesis of muscular symptomatology in the eosinophilia-myalgia syndrome (EMS).
METHODS
P31-nuclear magnetic resonance spectroscopy (MRS) was performed on 7 patients with EMS and 10 age matched controls to determine the relative concentrations of phosphocreatine (PCr), inorganic phosphate (Pi), and adenosine triphosphate (ATP) in calf muscle.
RESULTS
Patients with EMS had statistically lower ATP/PCr ratios and higher Pi/ATP ratios than controls, indicating a preferential and unique decrease in ATP levels at rest in skeletal muscle.
CONCLUSION
Skeletal muscle is metabolically abnormal in patients with EMS. This abnormality may contribute to the myalgia, spasm, and weakness seen in this disorder.
目的
确定嗜酸性粒细胞增多性肌痛综合征（EMS）中肌肉症状的发病机制。
方法
对7例EMS患者和10例年龄匹配的对照者进行小腿肌肉磷31核磁共振波谱分析（MRS），以测定磷酸肌酸（PCr）、无机磷酸盐（Pi）和三磷酸腺苷（ATP）的相对浓度。
结果
与对照组相比，EMS患者的ATP/PCr比值在统计学上较低，而Pi/ATP比值较高，表明静息状态下骨骼肌中的ATP水平存在优先且独特的降低。
结论
EMS患者的骨骼肌存在代谢异常。这种异常可能导致该疾病中出现的肌痛、痉挛和无力。
Zotero 插件