Krapf M W, Müller S, Mennet P, Stratz T, Samborski W, Müller W
Hochrhein-Institut für Rheumaforschung und Rheumaprävention, Bad Säckingen (D)/Rheinfelden, CH.
Z Rheumatol. 1992 Sep-Oct;51(5):229-37.
Using 31P nuclear magnetic resonance, the following parameters were determined in the resting musculus erector spinae of five patients suffering from chronic low back pain, five patients with fibromyalgia, and five healthy controls: Inorganic phosphate (Pi), phosphocreatine (PCr), ATP gamma, ATP alpha, ATP beta. The intracellular pH was derived from the chemical shift of Pi referenced to the PCr resonance. In addition, the Pi-Index was calculated according to the formula: Pi/(Pi + PCr). We discovered a tendency towards a shift of the Pi resonance in the alcalic direction, which was the larger, the stronger muscle spasm was found on palpation. The pH showed the most reliable relationship to the clinical status of muscle spasm. The surprising finding that there is no acidification within the spasmed muscle indicates that generalized hypoxia does not exist in this tissue. This has already been shown with PO2 measurements. An intracellular acidification is only recorded during maximal isometric contraction. Thus, ischemia cannot be responsible for pain experienced during muscle spasm.
利用31P核磁共振技术,测定了5例慢性下背痛患者、5例纤维肌痛患者以及5例健康对照者静息状态下竖脊肌的以下参数:无机磷酸盐(Pi)、磷酸肌酸(PCr)、ATPγ、ATPα、ATPβ。细胞内pH值由Pi相对于PCr共振的化学位移得出。此外,根据公式Pi/(Pi + PCr)计算Pi指数。我们发现Pi共振有向碱性方向偏移的趋势,触诊时发现的肌肉痉挛越强,这种偏移就越大。pH值与肌肉痉挛的临床状态显示出最可靠的关系。令人惊讶的发现是,痉挛肌肉内不存在酸化现象,这表明该组织不存在全身性缺氧。这一点已经通过PO2测量得到证实。细胞内酸化仅在最大等长收缩期间记录到。因此,缺血不可能是肌肉痉挛时疼痛的原因。