Merrick M J, Caten C E
J Gen Microbiol. 1975 Feb;86(2):283-93. doi: 10.1099/00221287-86-2-283.
In a sample of 52 wild-type isolates of Aspergillus nidulans, penicillin titre ranged from 0-0 to 14-4 units/ml. These differences in titre were under genetic control. Most of the variation between isolates was attributable to differences between heterokaryon-compatibility groups although significant differences were also found within groups. Genetic variation for penicillin titre was observed among the progeny in four of seven crosses between wild-type isolates. In these four crosses the variation was continuous, indicating that this is a polygenically determined character, and progeny with titres superior and inferior to those of the parents were produced. The genes determining penicillin production are predominantly additive in their action. Crosses between heterokaryon-incompatible isolates generated more genetic variation than those involving compatible parents, supporting the hypothesis that heterokaryon-compatible isolates are frequently closely related.
在52株构巢曲霉野生型分离株的样本中，青霉素效价范围为0.0至14.4单位/毫升。这些效价差异受遗传控制。分离株之间的大多数变异归因于异核体相容性组之间的差异，尽管在组内也发现了显著差异。在野生型分离株之间的七次杂交中的四次杂交的子代中观察到了青霉素效价的遗传变异。在这四次杂交中，变异是连续的，这表明这是一个多基因决定的性状，并且产生了效价高于和低于亲本的子代。决定青霉素产生的基因在其作用上主要是累加的。异核体不相容分离株之间的杂交比涉及相容亲本的杂交产生了更多的遗传变异，这支持了异核体相容分离株通常密切相关的假设。
