Honjoh Y, Nishimura Y, Kanomata N, Hanioka K, Itoh H, Kubota A
Department of Pathology, Kobe University School of Medicine, Japan.
Kobe J Med Sci. 1994 Feb;40(1):1-11.
Morphological studies were done on 109 placentae of 6 to 43 gestational weeks. Soft x-ray figures are useful for detecting the development of the placenta, which is closely correlated to enlargement of cotyledon and vascular growth in the chorionic villi. At histological figures, chorionic villi, corresponding to intermediate mature villi at the early gestational weeks, reveal large size with edematous stroma and prominent interstitial cells. Their size becomes smaller with aging, with decreased interstitial cells and stroma. At the early gestational period until 23 weeks, chorionic villi are lined by two cell layers of S-(syncytial) and C-(cytotrophoblastic) cells. After 24 gestational weeks C-inner lining decreases in number. Syncytial knots become marked after 32 weeks. As aging, the intervillous space becomes narrow and is occupied by the small sized terminal and mature chorionic villi with congestive capillaries. Syncytial knots and fibrin deposit around chorionic villi are increased with placental aging. By the immunohistoenzymatical examination, S-lining is positive by hCG (human Chorionic Gonadotropin) at the early gestation, but is markedly positive by hPL(human Placental Lactogen) and SP-1 (Specific Protein 1) lately.
对109个妊娠6至43周的胎盘进行了形态学研究。软X线图像有助于检测胎盘的发育情况，胎盘发育与绒毛叶增大及绒毛膜绒毛血管生长密切相关。在组织学图像上，对应于妊娠早期中间成熟绒毛的绒毛膜绒毛，体积较大，间质水肿，间质细胞突出。随着胎盘老化，其体积变小，间质细胞和间质减少。在妊娠早期直至23周，绒毛膜绒毛由S（合体滋养层）和C（细胞滋养层）两层细胞构成。妊娠24周后，C内层细胞数量减少。32周后合体结节明显。随着老化，绒毛间隙变窄，被小尺寸的终末绒毛和成熟绒毛膜绒毛占据，且有充血的毛细血管。随着胎盘老化，绒毛周围的合体结节和纤维蛋白沉积增加。通过免疫组织化学检查，妊娠早期S层对人绒毛膜促性腺激素（hCG）呈阳性反应，但后期对人胎盘催乳素（hPL）和特异性蛋白1（SP-1）呈明显阳性反应。
