Marder K, Maestre G, Cote L, Mejia H, Alfaro B, Halim A, Tang M, Tycko B, Mayeux R
G.H. Sergievsky Center, Columbia University, New York, NY 10032.
Neurology. 1994 Jul;44(7):1330-1. doi: 10.1212/wnl.44.7.1330.
The epsilon 4 isoform of apolipoprotein E (Apo-E) may confer genetic susceptibility for familial and sporadic Alzheimer's disease (AD). Because dementia in AD and Parkinson's disease (PD) share many biologic and clinical features, we determined the Apo-E genotypes for 79 patients with PD, 22 of whom were demented, and for 44 age-matched healthy elderly controls from the same community. We hypothesized that if the dementia was similar to AD, there would be a higher allele frequency of apolipoprotein epsilon 4 (Apo epsilon 4) in demented PD patients compared with nondemented PD patients and controls. The epsilon 4 allele frequency for PD without dementia was 0.132, for PD with dementia, 0.068, and for controls, 0.102. There was no association between Apo epsilon 4 and dementia in the PD patients. We conclude that the biologic basis for dementia in PD may differ from that of AD.
载脂蛋白E（Apo - E）的ε4异构体可能赋予家族性和散发性阿尔茨海默病（AD）遗传易感性。由于AD和帕金森病（PD）中的痴呆具有许多生物学和临床特征，我们确定了79例PD患者（其中22例患有痴呆）以及来自同一社区的44名年龄匹配的健康老年对照的Apo - E基因型。我们假设，如果PD中的痴呆与AD相似，那么与非痴呆的PD患者及对照相比，痴呆的PD患者中载脂蛋白ε4（Apo ε4）的等位基因频率会更高。无痴呆的PD患者中ε4等位基因频率为0.132，有痴呆的PD患者为0.068，对照为0.102。PD患者中Apo ε4与痴呆之间无关联。我们得出结论，PD中痴呆的生物学基础可能与AD不同。
