玻璃体切除术联合转化生长因子-β2治疗黄斑裂孔时眼内气泡持续时间的影响

Effects of intraocular bubble duration in the treatment of macular holes by vitrectomy and transforming growth factor-beta 2.

作者信息

Thompson J T, Glaser B M, Sjaarda R N, Murphy R P, Hanham A

机构信息

Retina Institute of Maryland, Baltimore.

出版信息

Ophthalmology. 1994 Jul;101(7):1195-200. doi: 10.1016/s0161-6420(94)31187-0.

DOI:10.1016/s0161-6420(94)31187-0

PMID:8035983

Abstract

PURPOSE

To compare the effect of a long-acting (16% perfluoropropane [C3F8]) versus a short-acting (air) intraocular gas tamponade on visual outcome and macular hole closure rate after vitrectomy and intravitreal instillation of transforming growth factor-beta 2 (TGF-beta 2) on the macula.

METHODS

Vitrectomy with removal of the posterior hyaloid fluid-gas exchange with instillation of TGF-beta 2 was performed in 15 eyes treated with air and 37 eyes treated with 16% C3F8 using identical surgical techniques (mean follow-up, 5.6 months).

RESULTS

The macular hole was closed successfully in 36 (97%) of 37 eyes treated with 16% C3F8 and in 8 (53.3%) of 15 eyes treated with air (P = 0.00007). The visual acuity improved by a mean of 3.1 lines on the Early Treatment of Diabetic Retinopathy Study chart for eyes treated with 16% C3F8 and 1.3 lines for eyes treated with air (P = 0.003).

CONCLUSIONS

A longer duration intraocular gas tamponade from 16% C3F8 gives a much higher rate of successful closure of macular holes and improved visual acuity using vitrectomy and TGF-beta 2 than does air.

摘要

目的

比较长效（16%全氟丙烷[C3F8]）与短效（空气）眼内气体填塞对玻璃体切除联合玻璃体内注射转化生长因子-β2（TGF-β2）至黄斑区后视力预后及黄斑裂孔闭合率的影响。

方法

采用相同手术技术，对15只接受空气治疗的眼睛和37只接受16% C3F8治疗的眼睛进行玻璃体切除，去除后玻璃体，进行液气交换并注射TGF-β2（平均随访5.6个月）。

结果

16% C3F8治疗的37只眼中有36只（97%）黄斑裂孔成功闭合，空气治疗的15只眼中有8只（53.3%）黄斑裂孔成功闭合（P = 0.00007）。在糖尿病视网膜病变早期治疗研究视力表上，接受16% C3F8治疗的眼睛视力平均提高3.1行，接受空气治疗的眼睛视力平均提高1.3行（P = 0.003）。