Sainz de la Maza M, Foster C S, Jabbur N S
Ocular Immunology Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston.
Ophthalmology. 1994 Jul;101(7):1281-6; discussion 1287-8.
Rheumatoid arthritis is the most common systemic immune-mediated condition associated with scleritis. The purpose of this study is to determine whether or not scleritis is more severe in patients with rheumatoid arthritis than in those without associated disease ("idiopathic scleritis"), or than in patients with other systemic immune-mediated diseases.
Patient characteristics, type of scleritis, and ocular complications of 32 patients with scleritis associated with rheumatoid arthritis were compared with those of 74 patients with idiopathic scleritis and with those of 50 patients with scleritis associated with other systemic immune-mediated diseases.
Patients with scleritis associated with rheumatoid arthritis were older (mean age, 60.78; P = 0.0011) and more often had necrotizing scleritis (34%; P = 0.0001), decrease in vision (59%; P = 0.0001), and peripheral ulcerative keratitis (31%; P = 0.0001) than patients with idiopathic scleritis; by contrast, there was no statistical association with sex, bilaterality, anterior uveitis, glaucoma, or cataract. Patients with scleritis associated with rheumatoid arthritis were older (P = 0.0261) and more often had bilateral scleritis (53%; P = 0.0221) than patients with scleritis associated with other systemic immune-mediated diseases; however, there was no statistical association with type of scleritis, sex, decrease in vision, anterior uveitis, peripheral ulcerative keratitis, glaucoma, or cataract.
Scleritis associated with rheumatoid arthritis is more severe than idiopathic scleritis but is as severe as scleritis associated with other immune-mediated diseases.
类风湿性关节炎是与巩膜炎相关的最常见的全身性免疫介导疾病。本研究的目的是确定类风湿性关节炎患者的巩膜炎是否比无相关疾病的患者（“特发性巩膜炎”）或患有其他全身性免疫介导疾病的患者更严重。
将32例类风湿性关节炎相关巩膜炎患者的患者特征、巩膜炎类型和眼部并发症与74例特发性巩膜炎患者以及50例其他全身性免疫介导疾病相关巩膜炎患者的进行比较。
与特发性巩膜炎患者相比，类风湿性关节炎相关巩膜炎患者年龄更大（平均年龄60.78岁；P = 0.0011），坏死性巩膜炎的发生率更高（34%；P = 0.0001），视力下降（59%；P = 0.0001），周边溃疡性角膜炎（31%；P = 0.0001）；相比之下，与性别、双侧性、前葡萄膜炎、青光眼或白内障无统计学关联。与其他全身性免疫介导疾病相关巩膜炎患者相比，类风湿性关节炎相关巩膜炎患者年龄更大（P = 0.0261），双侧巩膜炎的发生率更高（53%；P = 0.0221）；然而，与巩膜炎类型、性别、视力下降、前葡萄膜炎、周边溃疡性角膜炎、青光眼或白内障无统计学关联。
类风湿性关节炎相关巩膜炎比特发性巩膜炎更严重，但与其他免疫介导疾病相关巩膜炎的严重程度相同。
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