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Gene therapy: current and future implications for oncology nursing practice.基因治疗：对肿瘤护理实践的当前及未来影响
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癌症的基因治疗。

Gene therapy for cancer.

作者信息

Culver K W, Blaese R M

机构信息

Human Gene Therapy Research Institute, Iowa Methodist Medical Center, Des Moines 50309.

出版信息

Trends Genet. 1994 May;10(5):174-8. doi: 10.1016/0168-9525(94)90095-7.

DOI:10.1016/0168-9525(94)90095-7
PMID:8036720
Abstract

Initiation of clinical trials of gene therapies for cancer has been made possible by two major technological advances: the ability to clone genes that constitute the genetic basis of carcinogenesis or that have therapeutic potential, and the development of an increasing number of gene transfer methods. As a result, 30 experimental trials of gene therapy for the treatment of human cancer have been approved in the United States of America. Here, we discuss the current status of gene therapy for cancer together with future directions for its development.

摘要

两项重大技术进步使得癌症基因治疗临床试验的开展成为可能

一是能够克隆构成致癌作用遗传基础或具有治疗潜力的基因，二是开发出越来越多的基因转移方法。因此，美国已经批准了30项用于治疗人类癌症的基因治疗实验性试验。在此，我们将讨论癌症基因治疗的现状及其未来发展方向。