Zhong S B, Liu W C, Li R L, Ling Y Z, Li C H, Tu G Z, Ma L B, Hong S L
School of Pharmaceutical Sciences, Beijing Medical University.
Yao Xue Xue Bao. 1994;29(1):33-8.
Ten esters of cephalotaxine with amino acids possessing widely different structural features have been synthesized and tested for antitumor activity. Preliminary data showed that compound 6 is the most active one. However, it is still less potent than harringtonine. Other synthetic esters possess varying activities at 10 micrograms/ml. Preliminary structure activity relationship of these esters was discussed.
已经合成了十种具有广泛不同结构特征的头霉素与氨基酸的酯，并对其抗肿瘤活性进行了测试。初步数据表明化合物6是活性最高的一种。然而，它的效力仍低于三尖杉酯碱。其他合成酯在10微克/毫升时具有不同的活性。讨论了这些酯的初步构效关系。
