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[头霉素酯类似物的合成及其抗肿瘤活性]

[Synthesis of analogs of cephalotaxine esters and their antitumor activities].

作者信息

Wei D, Jiang Y Z, Zhao Z Z

机构信息

Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.

出版信息

Yao Xue Xue Bao. 1990;25(9):677-83.

PMID:2092575
Abstract

Four analogs of cephalotaxine esters (C1Z, C2E, C3E, C4E) were synthesized. The ratio of the Z, E isomers of the side chain alpha, beta-unsaturated ester carboxylic acids is reported. The Z isomer was easy to transform to the E isomer. Compound C1Z showed significant activity of inducing cancer cell HL-60 differentiation. It also showed inhibitory activity on Leukemia L1210.

摘要

合成了四种头霉素酯类似物（C1Z、C2E、C3E、C4E）。报道了侧链α，β-不饱和酯羧酸的Z、E异构体比例。Z异构体易于转化为E异构体。化合物C1Z显示出诱导癌细胞HL-60分化的显著活性。它对白血病L1210也显示出抑制活性。

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