Vogl T J, Mack M G, Juergens M, Stark M, Pegios W, Bergman C, Grevers G, Western A
Department of Radiology, University of Berlin, Rudolf Virchow Hospital, Germany.
AJR Am J Roentgenol. 1994 Aug;163(2):425-32. doi: 10.2214/ajr.163.2.8037044.
The purpose of this study was to compare the relative values of MR images obtained with a triple dose of gadodiamide and MR images obtained with the standard dose of gadopentetate dimeglumine for the detection and determination of the extent of tumors of the head and neck.
Forty-two patients with benign and malignant tumors of the head and neck were examined with contrast-enhanced MR imaging in a comparison of a triple dose of gadodiamide (0.3 mmol per kilogram body weight) and a standard dose (0.1 mmol per kilogram body weight) of gadopentetate dimeglumine. All patients underwent MR imaging with both doses of contrast material. Contrast-to-noise ratios and the percentage enhancement of normal and abnormal structures were calculated, and delineation of the lesion and the contrast between tumor and surrounding tissue were evaluated visually.
Statistical analysis (Friedman test and Wilcoxon test) of the contrast-to-noise ratios between tumor and white matter, the percentage enhancement, and the visual assessment rating revealed a statistically significant superiority of the triple dose of gadodiamide over the standard dose of gadopentetate dimeglumine. Tumor/muscle contrast-to-noise ratios were not significantly different with the two doses. The detection rate for tumors was no better with the triple dose of gadodiamide than with the standard dose of gadopentetate dimeglumine.
Use of the triple dose of gadodiamide results in a statistically significant improvement in the visual assessment rating, but it does not increase the number of tumors detected on MR images over the number detected with the standard dose of gadopentetate dimeglumine and does not appear to alter the differential diagnosis.
本研究的目的是比较使用三倍剂量钆双胺获得的磁共振成像（MR）图像与使用标准剂量钆喷酸葡胺获得的MR图像在检测和确定头颈部肿瘤范围方面的相对价值。
42名头颈部良性和恶性肿瘤患者接受了对比增强MR成像检查，比较三倍剂量钆双胺（每千克体重0.3 mmol）和标准剂量钆喷酸葡胺（每千克体重0.1 mmol）。所有患者均接受了两种剂量对比剂的MR成像检查。计算正常和异常结构的对比噪声比及增强百分比，并通过视觉评估病变的勾画以及肿瘤与周围组织之间的对比度。
对肿瘤与白质之间的对比噪声比、增强百分比和视觉评估评分进行统计分析（Friedman检验和Wilcoxon检验），结果显示三倍剂量钆双胺在统计学上显著优于标准剂量钆喷酸葡胺。两种剂量下肿瘤/肌肉对比噪声比无显著差异。三倍剂量钆双胺的肿瘤检出率并不比标准剂量钆喷酸葡胺更好。
使用三倍剂量钆双胺在视觉评估评分上有统计学上的显著改善，但与使用标准剂量钆喷酸葡胺相比，它并没有增加MR图像上检测到的肿瘤数量，且似乎不会改变鉴别诊断结果。
