Heywang-Köbrunner S H, Haustein J, Pohl C, Beck R, Lommatzsch B, Untch M, Nathrath W B
Department of Radiology, University of Halle, Germany.
Radiology. 1994 Jun;191(3):639-46. doi: 10.1148/radiology.191.3.8184040.
To optimize detection and diagnosis of breast lesions with contrast-enhanced magnetic resonance (MR) imaging.
A three-dimensional fast low-angle shot pulse sequence was used for a group comparison consisting of 76 high-dose (0.16 mmol gadopentetate dimeglumine per kilogram of body weight) and 76 low-dose (0.1 mmol/kg) examinations. Intraindividual comparisons were possible in a subgroup of 20 patients.
Enhancement with the high dose was about 1.5 times higher for benign and malignant tissues. With the lower dose, no false-positive findings could be avoided and definition of a threshold that excluded false-negative findings was problematic. Conspicuity of malignant lesions was much improved with the higher dose (a good to excellent rating in 81% vs 26% with the lower dose). Three small foci were visible only with the higher dose.
The higher dose of contrast material allowed much better results. Dose comparison studies are also recommended for other techniques.
通过对比增强磁共振（MR）成像优化乳腺病变的检测与诊断。
采用三维快速低角度激发脉冲序列对76例高剂量（每千克体重0.16 mmol钆喷酸葡胺）和76例低剂量（0.1 mmol/kg）检查进行组间比较。在20例患者的亚组中可以进行个体内比较。
高剂量时良性和恶性组织的强化约高1.5倍。使用较低剂量时，无法避免假阳性结果，且定义排除假阴性结果的阈值存在问题。高剂量时恶性病变的清晰度明显提高（81%为良好至优秀评级，而低剂量时为26%）。三个小病灶仅在高剂量时可见。
较高剂量的造影剂可产生更好的结果。也建议对其他技术进行剂量比较研究。
