Miyasaki K
Virchows Arch A Pathol Anat Histol. 1975;365(4):351-65. doi: 10.1007/BF00471182.
Water-soluble polymer compound, polyvinyl alcohol(PVA), and water-insoluble polymer compounds, polyvinyl acetate (PVAc) and polystylol (PS), were administered in 297 rabbits. When high polymerized PVA, PVAc or PS were continuously injected intravenously for a long period of time, lesions resembled to those of Gaucher and Niemann-Pick diseases were developed. From these experimental results, pathological development of various sphingolipidoses found in the human body was discussed and pathological findings were analysed polymer-chemically from the chemical properties of the substances stored.
将水溶性高分子化合物聚乙烯醇（PVA）以及水不溶性高分子化合物聚醋酸乙烯酯（PVAc）和聚苯乙烯（PS）注射到297只兔子体内。当长时间连续静脉注射高度聚合的PVA、PVAc或PS时，会出现类似于高雪氏病和尼曼-匹克病的病变。根据这些实验结果，对人体中发现的各种鞘脂类疾病的病理发展进行了讨论，并根据所储存物质的化学性质从高分子化学角度分析了病理结果。
