Goodman D H, Wert A D
Am Fam Physician. 1975 Mar;11(3):74-9.
Allergic asthma is caused by antigen reaction with IgE fixed to mast cells of the bronchi. The reaction causes release of slow-reacting substance of anaphylaxis and histamine, which cause bronchial constriction. Prophylactic treatment includes avoidance of antigens, desensitization and use of cromolyn sodium. The latter appears to impede release of chemical mediators by the mast cell. Although of no value during an acute attack, this agent reduces attacks and reduces the need for other drugs in patients with severe perennial asthma.
过敏性哮喘是由抗原与固定在支气管肥大细胞上的IgE发生反应引起的。该反应导致过敏反应迟缓反应物质和组胺的释放，从而引起支气管收缩。预防性治疗包括避免接触抗原、脱敏以及使用色甘酸钠。色甘酸钠似乎能阻止肥大细胞释放化学介质。虽然在急性发作期间没有作用，但这种药物能减少发作次数，并减少重度常年性哮喘患者对其他药物的需求。
