Numan M, Numan M J
Department of Psychology, Boston College, Chestnut Hill, Massachusetts 02167.
Behav Neurosci. 1994 Apr;108(2):379-94. doi: 10.1037//0735-7044.108.2.379.
This study uses Fos immunocytochemistry to show that the medial preoptic area and ventral bed nucleus of the stria terminalis are activated in maternally behaving female rats. In Experiment 1, virgin female rats that showed maternal behavior toward pups had more cells in these regions that expressed Fos-like immunoreactivity than did virgin females that were not maternally responsive. In Experiment 2, postpartum rats that were exposed to pups and showed maternal behavior had more Fos-labeled cells in these regions than did postpartum rats exposed to candy. Evidence also indicated that functional modifications in the medial amygdala were related to the changes in Fos expression observed in the preoptic area and ventral bed nucleus of the stria terminalis.
本研究采用Fos免疫细胞化学方法，以显示在表现出母性行为的雌性大鼠中，内侧视前区和终纹床核腹侧被激活。在实验1中，对幼崽表现出母性行为的未生育雌性大鼠，与没有母性反应的未生育雌性大鼠相比，这些区域中表达Fos样免疫反应性的细胞更多。在实验2中，接触幼崽并表现出母性行为的产后大鼠，与接触糖果的产后大鼠相比，这些区域中Fos标记的细胞更多。证据还表明，杏仁核内侧的功能改变与在内侧视前区和终纹床核腹侧观察到的Fos表达变化有关。
