Kemény L, Ruzicka T, Dobozy A, Michel G
Department of Dermatology, Albert Szent Györgyi Medical University, Szeged, Hungary.
Int Arch Allergy Immunol. 1994 Aug;104(4):317-22. doi: 10.1159/000236686.
Interleukin-8 (IL-8) is a potent chemotactic and proinflammatory cytokine, produced in the skin by a variety of cells in response to inflammatory stimuli. Recent studies suggest that in addition to its potent actions on leukocytes, IL-8 exerts a direct influence on several functions of human epidermal cells such as chemotaxis, Candida albicans killing activity or proliferation. The effects of IL-8 are mediated by binding to two types of specific high-affinity receptors which contain seven transmembrane domains typical of guanine nucleotide binding protein (G protein)-coupled receptors. In the skin, a broad spectrum of cells such as neutrophils, T lymphocytes, mast cells, dermal macrophages, endothelial cells and keratinocytes possess binding sites for IL-8. Recently, increased expression of epidermal IL-8 receptors has been observed in psoriasis an inflammatory and hyperproliferative skin disease. Since the effects of IL-8 may be modulated at the receptor level, the pharmacological manipulation of the IL-8 receptor may prove an important target for the therapy of skin diseases with increased IL-8 levels.
白细胞介素-8（IL-8）是一种强效的趋化性和促炎细胞因子，由皮肤中的多种细胞在炎症刺激下产生。最近的研究表明，IL-8除了对白细胞有强大作用外，还对人表皮细胞的多种功能产生直接影响，如趋化性、白色念珠菌杀伤活性或增殖。IL-8的作用是通过与两种特定的高亲和力受体结合介导的，这两种受体含有鸟嘌呤核苷酸结合蛋白（G蛋白）偶联受体典型的七个跨膜结构域。在皮肤中，多种细胞如中性粒细胞、T淋巴细胞、肥大细胞、真皮巨噬细胞、内皮细胞和角质形成细胞都具有IL-8的结合位点。最近，在银屑病（一种炎症性和过度增殖性皮肤病）中观察到表皮IL-8受体的表达增加。由于IL-8的作用可能在受体水平受到调节，因此对IL-8受体的药理操纵可能是治疗IL-8水平升高的皮肤病的一个重要靶点。
