Hanson M J
University of Pennsylvania School of Nursing, Philadelphia.
Am J Crit Care. 1994 May;3(3):177-84; quiz 185-6.
Research in human coronary heart disease has been conducted primarily on males; however, investigators have begun to focus research efforts on female subjects as well. A literature review that identified studies on women and coronary heart disease was done to describe modifiable risk factors for coronary heart disease in women. Several modifiable risk factors such as smoking, hypertension, and disorders of lipid metabolism previously identified for men are also risk factors for women. However, the mechanisms by which some of these risk factors work in women are different from those in men. Moreover, women have additional risk factors related to menopause and, in some cases, the use of oral contraceptives. Significant initial information has been gained concerning women and coronary heart disease risk factors. However, gaps persist in information regarding the individual and synergistic effects of risk factors for CHD in women.
关于人类冠心病的研究主要是在男性中进行的；然而，研究人员也已开始将研究重点放在女性受试者身上。我们进行了一项文献综述，确定了有关女性与冠心病的研究，以描述女性冠心病的可改变危险因素。先前确定的一些可改变危险因素，如吸烟、高血压和脂质代谢紊乱，对男性来说是危险因素，对女性来说也是危险因素。然而，其中一些危险因素在女性体内起作用的机制与在男性体内不同。此外，女性还有与绝经相关的其他危险因素，在某些情况下，还与口服避孕药的使用有关。关于女性与冠心病危险因素，我们已经获得了重要的初步信息。然而，关于女性冠心病危险因素的个体及协同作用的信息仍存在空白。
