Williams C J, Yeomans J D, Coughlan A K
St James's University Hospital, Leeds.
Br J Psychiatry. 1994 Apr;164(4):554-6. doi: 10.1192/bjp.164.4.554.
A 59-year-old man with chronic treatment-resistant depression developed severe cognitive impairment. The severity of depression and the mode of presentation led to difficulty in diagnosis between a dementing disorder and a depressive illness. The diagnostic conundrum was resolved by the use of sleep deprivation (SD), which demonstrated clear subjective and objective improvements in his condition. These changes were quantified by a range of psychometric tests, which showed that initial deficits in cognitive performance improved temporarily after SD, and these improvements were maintained after effective treatment of the depression with electroconvulsive therapy.
一名患有慢性难治性抑郁症的59岁男性出现了严重的认知障碍。抑郁症的严重程度和表现方式导致在痴呆症和抑郁症之间难以诊断。通过使用睡眠剥夺（SD）解决了诊断难题，睡眠剥夺显示出其病情有明显的主观和客观改善。这些变化通过一系列心理测量测试进行量化，结果表明认知表现的初始缺陷在睡眠剥夺后暂时改善，并且在用电休克疗法有效治疗抑郁症后这些改善得以维持。
