Tishkov I, Razboynikov S, Tchoukanov C, Shipkova P
Int Urol Nephrol. 1978;10(3):245-9. doi: 10.1007/BF02082033.
The authors have elaborated a biochemical technique for the assessment of the selectivity of proteinuria by means of the clearances of ceruloplasmin, haptoglobin and albumin. The results obtained in 69 patients were compared to those established by the method of Cameron and Blanford, as well as by the clearance of alpha2-macroglobulin. No significant differences were found in the indices of proteinuria, as determined by the proposed biochemical technique and by the method of Cameron and Blanford. Thus the diagnostic value of both methods to assess the selectivity of proteinuria could be considered as equal. The additional measurement of the selectivity of proteinuria by means of proteins with considerably high molecular weight (haptoglobin, alpha2-macroglobulin) gave the possibility of recording cases with severely impaired glomerular permeability. In this respect, the use of the clearance of haptoglobulin, particularly the phenotype Hp 2--2, provided valuable diagnostic information in cases in which the routine methods gave borderline values for the index of proteinuria.
作者们阐述了一种生化技术，通过铜蓝蛋白、触珠蛋白和白蛋白的清除率来评估蛋白尿的选择性。将69例患者的检测结果与卡梅隆（Cameron）和布兰福德（Blanford）方法以及α2-巨球蛋白清除率所确定的结果进行了比较。通过所提出的生化技术和卡梅隆与布兰福德方法测定的蛋白尿指标没有显著差异。因此，两种评估蛋白尿选择性的方法的诊断价值可被视为等同。借助分子量相当高的蛋白质（触珠蛋白、α2-巨球蛋白）额外测量蛋白尿的选择性，使得记录肾小球通透性严重受损的病例成为可能。在这方面，使用触珠球蛋白的清除率，特别是Hp 2--2表型，在常规方法得出的蛋白尿指标为临界值的病例中提供了有价值的诊断信息。
